Single cell RNA sequencing of hEDS tissue

Single Cell RNA sequencing technology is a new technique that allows us to investigate gene expression in individual cells, rather than as a whole tissue.  We are using this method to investigate skin samples from women with hEDS compared to women without hypermobility or chronic pain. We can determine if certain cells are present in differing proportions and if they are expressing genes differently.  So far, we have collected skin punch biopsies from 18 women with hEDS and 12 women without hypermobility or chronic pain.